Related Experiment Video
Updated: Jul 3, 2026

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
Published on: July 20, 2019
Tumor Necrosis Factor-alpha as a Treatment Target for the Cancer Anorexia/Weight Loss Syndrome
Aminah Jatoi1, Kostandinos Sideras, Phuong L Nguyen
1Department of Oncology, Mayo Clinic, Rochester, MN.
Abstract:
The cancer-associated anorexia/weight loss syndrome occurs in > 50% of patients with advanced cancer. Associated with negative quality of life and diminished survival, this syndrome carries a devastating impact on patients with cancer. To date, efforts to manage this syndrome effectively have fallen short. However, recent data with therapy that targets the inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) appear promising. This article discusses some of the preliminary data that suggest that further study of anti-TNF- alpha is warranted. It also describes the study design of an ongoing North Central Cancer Treatment Group trial that is aimed at treating this syndrome with the agent infliximab.
Related Concept Videos
Tumor Immunotherapy
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
The Tumor Microenvironment
Treatment Resistant Cancers
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
