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Related Concept Videos

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.

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Related Experiment Video

Updated: Jul 3, 2026

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
09:10

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

Integrating genotypic data with transcriptomic and proteomic data.

Denis C Shields1, Aisling M O'Halloran

  • 1Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland. dshields@rcsi.ie

Comparative and Functional Genomics
|July 17, 2008
PubMed
Summary
This summary is machine-generated.

Understanding genetic variation is key. New high-throughput methods link genetic differences to observable traits and protein changes, aiding the study of complex diseases.

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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

Related Experiment Videos

Last Updated: Jul 3, 2026

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
09:10

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
10:37

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

Area of Science:

  • Genetics and Genomics
  • Proteomics and Metabolomics
  • Systems Biology

Background:

  • Genotypic variation has traditionally been inferred from phenotypic, metabolic, or protein chemistry differences.
  • Technological advancements now enable direct visualization of DNA variation.
  • Studying phenotypic, metabolic, and protein variability remains crucial for understanding the functional impact of genetic variation.

Purpose of the Study:

  • To explore how high-throughput transcriptomics and proteomics can identify functional consequences of genetic variability.
  • To investigate the role of family and association studies in understanding genetic variation.
  • To advance the understanding of the genetic etiology of complex disorders.

Main Methods:

  • Application of high-throughput transcriptomics and proteomics to diverse populations.
  • Utilizing family studies for segregation analysis and linkage analysis with genetic markers.
  • Employing association studies on variant proteins to confirm cis-acting genetic variants.
  • Integrating family and association studies with proteomic and transcriptomic analyses.

Main Results:

  • High-throughput transcriptomics and proteomics can reveal functional consequences of genetic variability through mRNA expression and protein quantity/property differences.
  • Family studies can delineate the genetic component and map causative factors.
  • Association studies effectively confirm cis-acting genetic variants.
  • Combined study designs offer powerful insights.

Conclusions:

  • Integrating multi-omics data (transcriptomics, proteomics) with genetic studies (family, association) enhances the understanding of genetic variation's functional impact.
  • These integrated approaches are vital for elucidating the genetic basis of complex diseases.
  • Future research should leverage these powerful combined methodologies.