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Related Concept Videos

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Related Experiment Video

Updated: Jul 3, 2026

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information
05:01

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information

Published on: July 1, 2020

MaizeDB - a functional genomics perspective.

Mary Polacco1, Ed Coe, Zhiwei Fang

  • 1USDA-ARS, USA. PolaccoM@missouri.edu

Comparative and Functional Genomics
|July 17, 2008
PubMed
Summary
This summary is machine-generated.

MaizeDB is a functional genomics tool for maize, offering new data access methods. It provides probe tables, BLAST access to genetic map data, and comparative mapping tools.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Plant Science

Background:

  • MaizeDB has been a genome-specific database since the early 1990s.
  • It is grounded in genetic maps, documentation, and annotation.
  • The database utilizes a robust Sybase management system.

Purpose of the Study:

  • To introduce MaizeDB as a functional genomics tool.
  • To highlight new data access features.
  • To showcase advancements in maize genetic information management.

Main Methods:

  • Review of MaizeDB functionalities.
  • Description of new data access points: probe tables by bin location.
  • Introduction to BLAST access for map data and cMap for comparative mapping.

Main Results:

  • MaizeDB serves as a valuable functional genomics resource.
  • New access methods enhance data retrieval and analysis.
  • Comparative mapping is facilitated through the cMap tool.

Conclusions:

  • MaizeDB provides essential tools for maize genomics research.
  • The database's new features improve accessibility and utility.
  • It supports advanced comparative genomics studies in maize.