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Updated: Jul 3, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
Published on: November 3, 2011
The prediction of membrane protein structure and genome structural annotation
Pier Luigi Martelli1, Piero Fariselli, Gianluca Tasco
1Laboratory of Biocomputing, CIRB/Department of Biology, University of Bologna, via Irnerio 42, Bologna 40126, Italy.
Abstract:
New methods, essentially based on hidden Markov models (HMM) and neural networks (NN), can predict the topography of both beta-barrel and all-alpha membrane proteins with high accuracy and a low rate of false positives and false negatives. These methods have been integrated in a suite of programs to filter proteomes of Gram-negative bacteria, searching for new membrane proteins.
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