Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Pleiotropy01:33

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
Lethal Alleles02:41

Lethal Alleles

Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Genetic Lingo01:11

Genetic Lingo

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inclusive Search for Anomalous Single-Photon Production in MicroBooNE.

Physical review letters·2026
Same author

First Search for Dark Sector e^{+}e^{-} Explanations of the MiniBooNE Anomaly at MicroBooNE.

Physical review letters·2026
Same author

First Measurement of Charged-Current Muon-Neutrino-Induced K^{+} Production on Argon Using the MicroBooNE Detector.

Physical review letters·2026
Same author

Search for an Anomalous Production of Charged-Current ν_{e} Interactions without Visible Pions across Multiple Kinematic Observables in MicroBooNE.

Physical review letters·2025
Same author

First Measurement of ν_{e} and ν[over ¯]_{e} Charged-Current Single Charged-Pion Production Differential Cross Sections on Argon Using the MicroBooNE Detector.

Physical review letters·2025
Same author

First Double-Differential Cross Section Measurement of Neutral-Current π^{0} Production in Neutrino-Argon Scattering in the MicroBooNE Detector.

Physical review letters·2025

Related Experiment Video

Updated: Jul 3, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
09:37

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

Ontologies for the description of mouse phenotypes.

G V Gkoutos1, E C J Green, A-M Mallon

  • 1MRC Mammalian Genetics Unit, Harwell, Oxfordshire OX11 0RD, UK. g.gkoutos@har.mrc.ac.uk

Comparative and Functional Genomics
|July 17, 2008
PubMed
Summary

This study introduces a new schema for describing biological phenotypes using ontologies, improving data storage and retrieval. This approach enhances the detailed description of organism phenotypes and facilitates biological data mining.

More Related Videos

Mouse Eye Enucleation for Remote High-throughput Phenotyping
05:30

Mouse Eye Enucleation for Remote High-throughput Phenotyping

Published on: November 19, 2011

Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station (INBEST)
12:18

Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station (INBEST)

Published on: April 23, 2015

Related Experiment Videos

Last Updated: Jul 3, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
09:37

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

Mouse Eye Enucleation for Remote High-throughput Phenotyping
05:30

Mouse Eye Enucleation for Remote High-throughput Phenotyping

Published on: November 19, 2011

Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station (INBEST)
12:18

Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station (INBEST)

Published on: April 23, 2015

Area of Science:

  • Bioinformatics
  • Ontology Engineering
  • Genomics

Background:

  • Ontologies are crucial for managing biological data.
  • Describing phenotypes with ontologies presents significant challenges.
  • Existing methods lack flexibility and extensibility.

Purpose of the Study:

  • To present a novel schema for phenotype description using combined ontologies.
  • To introduce tools for managing complex ontologies.
  • To enable robust linking of biological data to phenotypic descriptions.

Main Methods:

  • Combined orthologous axiomatic ontologies for phenotype representation.
  • Developed tools for ontology storage, browsing, and searching.
  • Linked assays (measurement protocols) to ontologies for data annotation.

Main Results:

  • Successfully annotated 600,000 mutant mouse phenotypes using the SHIRPA protocol.
  • Demonstrated the schema's ability to link organisms to phenotype ontologies.
  • Validated the flexibility and extensibility of the proposed approach.

Conclusions:

  • The developed schema provides a flexible and extensible method for detailed phenotype description.
  • This approach significantly improves biological data management and mining.
  • Applicable to describing phenotypes across diverse organisms.