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Related Concept Videos

DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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Navigating public microarray databases.

Christopher J Penkett1, Jürg Bähler

  • 1The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK. cjp@sanger.ac.uk

Comparative and Functional Genomics
|July 17, 2008
PubMed
Summary
This summary is machine-generated.

Public microarray databases store vital genome-wide expression data for research. This guide helps scientists navigate these resources, including ArrayExpress, to enhance their studies.

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Area of Science:

  • Bioinformatics
  • Genomics
  • Data Science

Background:

  • Genome-wide microarray studies generate vast amounts of data.
  • Effective data management and accessibility are crucial for scientific advancement.
  • Public databases play a key role in archiving and sharing expression data.

Purpose of the Study:

  • To provide a comprehensive guide to public microarray databases.
  • To assist researchers in utilizing existing expression data.
  • To highlight the importance of data archiving for complementary research.

Main Methods:

  • Review and categorization of existing public microarray databases.
  • Description of data content in repositories (raw vs. processed).
  • Explanation of specialized databases and their analytical focus.

Main Results:

  • Identification of large public repositories (e.g., ArrayExpress) and specialized databases.
  • Differentiation between data types offered (raw, processed, normalized).
  • Emphasis on the utility of these resources for augmenting individual research.

Conclusions:

  • Public microarray databases are essential resources for the scientific community.
  • Researchers can leverage these databases to complement and enhance their own studies.
  • Understanding the landscape of available databases facilitates efficient data discovery and utilization.