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Updated: Jul 3, 2026

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
Published on: August 14, 2018
Correct assignment of homology is crucial when genomics meets molecular evolution
Mohamed Zouine1, Quentin Sculo, Bernard Labedan
1Evolution Moleculaire et Genomique, Institut de Genetique et Microbiologie, CNRS UMR 8621, Universite Paris-Sud, Batiment 409, 91405 Orsay Cedex, France.
Abstract:
Pertinent evolutionary studies are based on a correct use of homology terms such as paralogues, metalogues and orthologues. Such crucial concepts have been applied to intragenomic and intergenomic analyses. A further requisite is a proper definition of what is a structural segment of homology. Such segments are called modules to reflect that they play a role in the mechanism of combinational construction of a gene from ready-made basic components. Since identifying a module is operationally equivalent to determining the ancestor to this gene segment, it becomes possible to track back protein history and genome evolution. Such studies underline the importance of two fundamental processes, gene duplication and gene fusion. Moreover, grouping the closest orthologues in families is a pertinent way to reconstruct a genomic tree for all available prokaryotes.
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