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Updated: Jul 3, 2026

Mouse Genome Engineering Using Designer Nucleases

Mouse Genome Engineering Using Designer Nucleases

Published on: April 2, 2014

Harvesting the mouse genome.

Marc Botcherby¹

¹MRC UK HGMP Resource Centre, Genome Campus, Hinxton, Cambridge CB10 1SB, UK. mrbotche@hgmp.mrc.ac.uk

Comparative and Functional Genomics

|July 17, 2008

Summary

This summary is machine-generated.

The black 6 mouse genome sequencing is nearing completion. This progress enables in-depth comparative analysis of targeted regions and promises a fully sequenced genome.

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Area of Science:

Genomics
Comparative genomics
Mouse genetics

Background:

The C57BL/6 mouse is a widely used model organism in biomedical research.
Advancements in sequencing technologies have enabled large-scale genome projects.
Previous efforts have established a BAC fingerprint map and shotgun assembly for the C57BL/6 mouse genome.

Purpose of the Study:

To review the progress of the C57BL/6 mouse genome sequencing project.
To highlight the current stage of BAC-by-BAC sequencing.
To discuss the potential for comparative genomic analysis using the assembled sequence data.

Main Methods:

End-sequencing of Bacterial Artificial Chromosomes (BACs).
Whole-genome shotgun sequencing with seven-fold coverage.
Assembly of sequence data.
BAC-by-BAC sequencing phase.

Main Results:

Near completion of the BAC fingerprint map.
Successful assembly of a seven-fold coverage whole-genome shotgun sequence.
Initiation of the BAC-by-BAC sequencing phase.

Conclusions:

The C57BL/6 mouse genome sequencing is at a critical stage.
The ongoing sequencing efforts will facilitate detailed comparative analyses.
The completion of the mouse genome sequence holds significant promise for future research.