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In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.

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Related Experiment Video

Updated: Jul 3, 2026

Mouse Genome Engineering Using Designer Nucleases
12:04

Mouse Genome Engineering Using Designer Nucleases

Published on: April 2, 2014

Harvesting the mouse genome.

Marc Botcherby1

  • 1MRC UK HGMP Resource Centre, Genome Campus, Hinxton, Cambridge CB10 1SB, UK. mrbotche@hgmp.mrc.ac.uk

Comparative and Functional Genomics
|July 17, 2008
PubMed
Summary
This summary is machine-generated.

The black 6 mouse genome sequencing is nearing completion. This progress enables in-depth comparative analysis of targeted regions and promises a fully sequenced genome.

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Last Updated: Jul 3, 2026

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Area of Science:

  • Genomics
  • Comparative genomics
  • Mouse genetics

Background:

  • The C57BL/6 mouse is a widely used model organism in biomedical research.
  • Advancements in sequencing technologies have enabled large-scale genome projects.
  • Previous efforts have established a BAC fingerprint map and shotgun assembly for the C57BL/6 mouse genome.

Purpose of the Study:

  • To review the progress of the C57BL/6 mouse genome sequencing project.
  • To highlight the current stage of BAC-by-BAC sequencing.
  • To discuss the potential for comparative genomic analysis using the assembled sequence data.

Main Methods:

  • End-sequencing of Bacterial Artificial Chromosomes (BACs).
  • Whole-genome shotgun sequencing with seven-fold coverage.
  • Assembly of sequence data.
  • BAC-by-BAC sequencing phase.

Main Results:

  • Near completion of the BAC fingerprint map.
  • Successful assembly of a seven-fold coverage whole-genome shotgun sequence.
  • Initiation of the BAC-by-BAC sequencing phase.

Conclusions:

  • The C57BL/6 mouse genome sequencing is at a critical stage.
  • The ongoing sequencing efforts will facilitate detailed comparative analyses.
  • The completion of the mouse genome sequence holds significant promise for future research.