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Updated: Jul 3, 2026

Bacterial Gene Expression Analysis Using Microarrays
Published on: May 28, 2007
Microarray analysis of bacterial gene expression: towards the regulome
Sharon L Kendall1, Farahnaz Movahedzadeh, Andreas Wietzorrek
1Department of Pathology and Infectious Diseases, Royal Veterinary College, Royal College Street, London NW1 0TU, UK. skendall@rvc.ac.uk
Abstract:
Microarray technology allows co-regulated genes to be identified. In order to identify genes that are controlled by specific regulators, gene expression can be compared in mutant and wild-type bacteria. However, there are a number of pitfalls with this approach; in particular, the regulator may not be active under the conditions in which the wild-type strain is cultured. Once co-regulated genes have been identified, proteinbinding motifs can be identified. By combining these data with a map of promoters, or operons (the operome), the regulatory networks in the cell (the regulome) can start to be built up.
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