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Related Concept Videos

Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved DNA...
RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while microarray-based...
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
Chromosome Structure02:40

Chromosome Structure

A functional eukaryotic chromosome must contain three elements: a centromere, telomeres, and numerous origins of replication.
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Homologous Recombination02:31

Homologous Recombination

The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of these sequences uses a strand from another as a template to synthesize DNA in an enzyme-catalyzed reaction. The final product is a novel amalgamation of the two substrates. To ensure an accurate recombination of sequences, HR is restricted to the S and G2 phases of the cell cycle. At these stages, the DNA has been replicated already and the...
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

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Updated: Jul 3, 2026

The ITS2 Database
16:17

The ITS2 Database

Published on: March 12, 2012

SSRD: simple sequence repeats database of the human genome.

Subbaya Subramanian1, Vamsi M Madgula, Ranjan George

  • 1Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India.

Comparative and Functional Genomics
|July 17, 2008
PubMed
Summary

The Simple Sequence Repeats Database (SSRD) provides comprehensive human genome data on simple sequence repeats (SSRs). This resource aids in analyzing SSR distribution, aiding genetic diversity studies and disease marker identification.

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Electrophoretic Analysis of Replication Through Structure-Prone DNA Repeats Within the SV40-Based Human Episome

Published on: September 13, 2024

Area of Science:

  • Genomics
  • Molecular Biology
  • Bioinformatics

Background:

  • Simple sequence repeats (SSRs) are abundant in genomes and crucial for genetic diversity studies.
  • SSRs serve as valuable diagnostic markers for various diseases.
  • Understanding SSR distribution and function is vital for genomic research.

Purpose of the Study:

  • To create a centralized database (SSRD) for human simple sequence repeats.
  • To facilitate easy access, analysis, and understanding of SSRs' biological significance.
  • To provide insights into the functional and evolutionary roles of SSRs.

Main Methods:

  • Data compilation of SSR abundance and distribution in the human genome.
  • Annotation of SSR locations within coding, non-coding, and UTR regions.
  • Association analysis of SSRs with STS markers.

Main Results:

  • Detailed information on SSR abundance and distribution across genomic regions.
  • Identification of SSR associations with UTRs, exons, introns, and intergenic regions.
  • Mapping of SSRs relative to STS markers.

Conclusions:

  • The SSRD enhances the analysis of human simple sequence repeats.
  • Facilitates a deeper understanding of the functional and evolutionary importance of SSRs.
  • Provides a valuable resource for genetic research and disease diagnostics.