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Related Concept Videos

Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...

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Updated: Jul 3, 2026

Cranial Neural Crest Cells Three-Dimensional In Vitro Differentiation Protocol for Multiplexed Assay
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Reprogramming multipotent tumor cells with the embryonic neural crest microenvironment.

Jennifer C Kasemeier-Kulesa1, Jessica M Teddy, Lynne-Marie Postovit

  • 1Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|July 17, 2008
PubMed
Summary

The embryonic microenvironment can reprogram tumor cells, similar to how it guides embryonic development. Studying neural crest cells in embryos may reveal new cancer therapies by understanding tumor cell plasticity.

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Isolation and Culture of Neural Crest Cells from Embryonic Murine Neural Tube
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Published on: June 2, 2012

Area of Science:

  • Developmental Biology
  • Cancer Biology
  • Cellular Plasticity

Background:

  • Embryonic microenvironments program cell fate and migration.
  • Aggressive tumor cells share traits with multipotent embryonic progenitors.
  • The neural crest is a model for cell diversification and invasiveness.

Purpose of the Study:

  • To explore the embryonic microenvironment's potential to reprogram tumor cells.
  • To identify therapeutic targets by converging developmental and cancer biology signals.
  • To summarize common markers between neural crest cells and melanoma cells.

Main Methods:

  • Reviewing studies of tumor cells in embryonic models, particularly the chick neural crest.
  • Analyzing common markers between neural crest and aggressive melanoma cells.
  • Highlighting advances in understanding tumor cell plasticity in the chick neural crest microenvironment.

Main Results:

  • Tumor cells transplanted into embryonic models show potential for phenotype reversion.
  • The chick neural crest microenvironment can influence tumor cell behavior and plasticity.
  • Common markers identified between neural crest and melanoma cells.

Conclusions:

  • The embryonic microenvironment offers a model for understanding and potentially controlling tumor cell invasion and metastasis.
  • Further research may lead to novel therapeutic strategies by integrating developmental and cancer biology insights.
  • This work honors Professor Elizabeth D. Hay's contributions to developmental and cancer biology.