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Heparan sulfate proteoglycans: a GAGgle of skeletal-hematopoietic regulators

Kathryn D Rodgers1, James D San Antonio, Olena Jacenko

  • 1Department of Animal Biology, Division of Biochemistry, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania 19104-6046, USA. krodgers@vet.upenn.edu

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|July 17, 2008
PubMed

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Regulation of Hematopoietic Stem Cells

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Role of Hematopoietic Growth Factors

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Proteoglycans

Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
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Matrix Proteoglycans and Glycoproteins

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Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...