Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
Chronopharmacokinetics: Time-Dependent Pharmacokinetics01:20

Chronopharmacokinetics: Time-Dependent Pharmacokinetics

Chronopharmacokinetics studies the temporal change in drug absorption and elimination. These changes can be cyclical or non-cyclical. Cyclical changes occur over a regular interval, while non-cyclical changes occur over a longer, irregular period.
Time-dependent pharmacokinetics refers to non-cyclical changes in drug rate processes over a period of time. It can lead to nonlinear pharmacokinetics, where the relationship between drug concentration and time is not proportional. Non-cyclical...
Methods of Documentation II: POMR01:26

Methods of Documentation II: POMR

The Problem-Oriented Medical Record (POMR) revolutionized medical record-keeping by introducing a systematic approach focusing on the patient's problems rather than merely listing symptoms. Dr. Lawrence Weed's introduction of this method in the 1960s marked a significant advancement in medical documentation. The POMR framework consists of four key components: the database, problem list, plan of care, and progress notes.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An Obstructive Sleep Apnea - A Novel Public Health Threat.

Physiological research·2023
Same author

General anesthesia and electrocardiographic parameters in in vivo experiments involving rats.

Physiological research·2022
Same author

Strong coincidence between slow wave sleep and low AHI is explainable by the high instability of slow wave sleep to obstructive apnea exposure.

Physiological research·2019
Same author

Arterial pH and blood gas values in rats under three types of general anesthesia: a chronobiological study.

Physiological research·2018
Same author

Thoughts on anaesthesia in chronobiological studies with electrocardiograms.

Acta physiologica (Oxford, England)·2016
Same author

Environmental estrogen bisphenol A and autoimmunity.

Lupus·2015

Related Experiment Video

Updated: Jul 3, 2026

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World
10:16

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World

Published on: April 7, 2020

[Chronobiology and practical medicine].

P Svorc1, I Bracoková, I Bacová

  • 1Ustav fyziológie, Lekárska fakulta Univerzity P J Safárika, Kosice. psvorc@lf.upjs.sk

Ceskoslovenska Fysiologie
|July 17, 2008
PubMed
Summary
This summary is machine-generated.

Understanding circadian rhythms is crucial for accurate medical diagnostics and effective therapies. Incorporating chronobiology improves patient health outcomes by accounting for biological variability.

More Related Videos

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

Related Experiment Videos

Last Updated: Jul 3, 2026

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World
10:16

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World

Published on: April 7, 2020

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

Area of Science:

  • Chronobiology
  • Clinical Medicine
  • Physiology

Context:

  • Current health assessments lack robust definitions of 'healthy' in relation to environmental adaptability.
  • Clinical medicine increasingly recognizes the significance of circadian rhythmicity in disease manifestation and symptom patterns.
  • Conventional clinical trials often overlook patient biological dynamism and time-dependent factors.

Purpose:

  • To highlight the importance of chronobiological principles in medical diagnostics and therapy.
  • To demonstrate how considering biological variability can enhance diagnostic accuracy and therapeutic efficacy.
  • To introduce and advocate for the adoption of specific chronobiological terminology in medical research and practice.

Summary:

  • The study emphasizes that current methods for defining health are insufficient, failing to account for an organism's dynamic response to environmental changes.
  • It illustrates through clinical examples how integrating chronobiology into medical diagnostics and treatment can significantly improve functional examination accuracy and therapeutic outcomes.
  • The paper addresses the need for standardized terminology in chronobiology to facilitate broader understanding and application among healthcare professionals.

Impact:

  • Improved accuracy in medical diagnostics and functional examinations.
  • Enhanced therapeutic efficacy and safety through time-dependent drug administration.
  • Facilitation of wider adoption of chronobiological principles in clinical practice and research.
  • Potential for better patient health outcomes by acknowledging individual biological rhythms.