Related Experiment Video

Updated: Jul 3, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

[Growth retardation in children with obstructive sleep apnea hypopnea syndrome]

Jin Hou1, Quan-Qing Kang, Guo-Xi Zheng

  • 1Department of Otorhinolaryngology, Second Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710004, China.

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Chinese Journal of Otorhinolaryngology Head and Neck Surgery
|July 17, 2008
PubMed

Insights

Children with obstructive sleep apnea syndrome (OSAS) experience growth delays. Treating OSAS accelerates growth and increases insulin-like growth factor-1 (IGF-1) levels in prepubertal children.

Area of Science:

  • Pediatric Endocrinology
  • Sleep Medicine
  • Growth and Development

Context:

  • Obstructive sleep apnea syndrome (OSAS) is prevalent in children and may impact growth.
  • Prepubertal children with OSAS often exhibit impaired growth parameters and lower IGF-1 levels.
  • Understanding the effects of OSAS treatment on growth is crucial for pediatric health.

Purpose:

  • To investigate the impact of treating obstructive sleep apnea syndrome (OSAS) on growth, body composition, and insulin-like growth factor-1 (IGF-1) levels in prepubertal children.
  • To compare growth outcomes in children with OSAS post-surgery versus a healthy control group.
  • To establish a correlation between OSAS resolution and biochemical markers of growth.

Summary:

  • Children with OSAS showed significantly lower height and IGF-1 levels compared to controls.
  • Following surgical treatment for OSAS, patients demonstrated significant increases in height and IGF-1 levels, reaching those of the control group within one year.
  • Post-operative improvements in oxygen saturation and reduced apnea-hypopnea index (AHI) were observed, correlating with enhanced growth markers.

Impact:

  • The findings suggest that treating OSAS can reverse growth retardation in children.
  • This study highlights the importance of addressing sleep-disordered breathing to optimize pediatric growth and development.
  • The results provide evidence for the role of IGF-1 as a marker for growth recovery after OSAS treatment.
Abstract

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