Related Experiment Video

Updated: Jul 3, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

[Influence on antidiuretic hormone secretion in children with obstructive sleep apnea hypopnea syndrome]

Zhi-Yong Yue1, Ming-Ming Wang, Hong Li

  • 1Department of Otorhinolaryngology, Shandong Provincial Hospital, Shandong University, Jinan 250021, China.

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Chinese Journal of Otorhinolaryngology Head and Neck Surgery
|July 17, 2008
PubMed

Insights

Obstructive sleep apnea hypopnea syndrome (OSAHS) in children is linked to lower antidiuretic hormone (ADH) levels. Adenotonsillectomy normalizes ADH secretion and improves sleep patterns in these patients.

Area of Science:

  • Pediatric Endocrinology
  • Sleep Medicine
  • Otolaryngology

Context:

  • Obstructive sleep apnea hypopnea syndrome (OSAHS) is prevalent in children.
  • Adenotonsillar hypertrophy is a common cause of pediatric OSAHS.
  • Sleep-disordered breathing can impact hormonal regulation.

Purpose:

  • To investigate the effect of pediatric obstructive sleep apnea hypopnea syndrome (OSAHS) on antidiuretic hormone (ADH) secretion.
  • To evaluate changes in ADH levels following adenotonsillectomy in children with OSAHS.

Summary:

  • Thirty pediatric patients with OSAHS underwent polysomnography and blood sampling for ADH levels before and after adenotonsillectomy. Twenty healthy children served as controls.
  • Preoperative OSAHS patients exhibited significantly lower serum ADH levels and increased nycturia volume compared to controls.
  • Post-adenotonsillectomy, OSAHS patients showed normalized ADH levels and reduced nycturia, with no statistical difference compared to healthy children.

Impact:

  • Adenotonsillectomy effectively restores normal antidiuretic hormone (ADH) secretion in children with OSAHS.
  • Surgical intervention improves sleep patterns and hormonal balance in pediatric OSAHS.
  • Findings highlight the link between OSAHS, ADH regulation, and nocturnal enuresis in children.
Abstract

Related Concept Videos

Diabetes Insipidus II: Pathophysiology01:22

Diabetes Insipidus II: Pathophysiology

Normally, water balance is maintained through three interconnected mechanisms: the hypothalamic thirst center, the synthesis and release of antidiuretic hormone (ADH, or vasopressin), and the kidneys' responsiveness to this hormone. ADH is synthesized in the hypothalamus, released from the posterior pituitary, and acts on the distal nephron, allowing water reabsorption and concentrated urine production.Diabetes Insipidus and Its TypesIn diabetes insipidus (DI), this regulatory system is...
Sleep Apnea01:21

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
Hormonal Regulation of Blood Pressure01:17

Hormonal Regulation of Blood Pressure

Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction while...
Antihypertensive Drugs: Potassium-Sparing Diuretics01:28

Antihypertensive Drugs: Potassium-Sparing Diuretics

Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
Antihypertensive Drugs: Thiazide-Class Diuretics01:15

Antihypertensive Drugs: Thiazide-Class Diuretics

Thiazide diuretics are sulfonamide derivatives featuring a benzothiadiazine ring system in their molecular structure. Based on this structure, thiazide diuretics can be categorized into two groups: thiazide-type and thiazide-like diuretics. Thiazide-type diuretics, including hydrochlorothiazide and chlorothiazide, consist of a benzothiadiazine backbone with an attached sulfonamide group. Thiazide-like diuretics, such as chlorthalidone and indapamide, lack the thiazide ring but demonstrate...