[Diabetes, dyslipidaemia and kidney diseases]
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Insights
Dyslipidemia (DLP), diabetes mellitus (DM), and kidney disorders are significant cardiovascular disease (CVD) risk factors. This review highlights DLP management in diabetic and kidney patients, focusing on hypolipidemic therapy
Area of Science:
- Cardiology
- Nephrology
- Endocrinology
Context:
- Dyslipidemia (DLP) is a primary risk factor for cardiovascular diseases (CVD).
- Diabetes Mellitus (DM) and kidney disorders are increasingly recognized as significant CVD risk indicators.
- Patients with kidney disorders share similar CVD risk levels with those with established atherosclerotic disease or DM.
Purpose:
- To highlight the significant and growing clinical relevance of the interplay between DLP, DM, and nephropathy.
- To review management strategies for diabetic dyslipidemia.
- To examine the role of DLP in kidney disorders and the impact of hypolipidemic therapy on cardiovascular risk and renal function.
Summary:
- The article discusses diabetic DLP and its management options.
- It explores the role of DLP in kidney disorders, associated risks, and management approaches.
- Intervention studies investigating hypolipidemic therapy's effects on CV risk and renal function markers are reviewed.
Impact:
- Emphasizes the critical need to address DLP in patients with DM and kidney disease.
- Provides insights into therapeutic strategies for managing DLP in these high-risk populations.
- Underscores the dual benefit of hypolipidemic therapy in reducing CVD risk and potentially improving renal outcomes.
Abstract:
Dyslipidemia (DLP) is the most significant risk factor for cardiovascular diseases (CVD). Similarly, the relevance of diabetes mellitus (DM) as a CVD risk indicator is so high that it is attributed the same significance as the secondary prevention ofCVD in different systems of global cardiovascular risk assessment. Most recently, also kidney disorders have been increasingly referred to as a risk factor for the manifestation of CVD. According to some guidelines, patients with kidney disorders are at the same risk as the patients with manifest IHD (or another manifestation of atherosclerosis), and patients with DM. This paper does not pretend to resolve the complex relationship between DLP, DM and nephropathy. Its sole objective is to bring attention to the fact that it is a relevant and significant issue which is gradually becoming a central point of attention. The first part of the article deals primarily with diabetic DLP and the different options for its management. The second part deals with the role of DLP in kidney disorders, the risk it represents and the options for its management, as well as with the results of the first intervention studies. The studies focused on the effect of hypolipidemic therapy on CV risk of patients on the one hand and, on the other hand, on the way hypolipidemic drugs contribute to the improvement or sustaining of renal functions, or on their influence on renal disease markers.
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