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Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

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Published on: March 20, 2015

Controlled plasmonic nanostructures for surface-enhanced spectroscopy and sensing.

Jon P Camden¹, Jon A Dieringer, Jing Zhao

¹Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA.

Accounts of Chemical Research

|July 18, 2008

Summary

Surface-enhanced Raman spectroscopy (SERS) is a powerful analytical technique. Recent advances in reproducible SERS substrates and single-molecule detection are revitalizing its use in diverse applications.

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Area of Science:

Analytical Chemistry
Spectroscopy
Nanotechnology

Background:

Surface-enhanced Raman spectroscopy (SERS) has long promised significant impact due to its sensitivity.
Historically, limited reproducibility in fabrication methods hindered SERS applications.
Recent advancements have spurred a renaissance in SERS research and development.

Purpose of the Study:

To highlight recent advancements in SERS, focusing on reproducible substrates and single-molecule detection.
To explore the fundamentals of SERS, including electromagnetic enhancement mechanisms.
To demonstrate the analytical capabilities of improved SERS techniques.

Main Methods:

Development of reproducible, stable SERS substrates with large field enhancement.
Investigating wavelength and distance dependence of SERS signals.
Utilizing isotopic labeling for single-molecule SERS studies on rhodamine 6G/silver systems.

Main Results:

Demonstrated SERS substrates with high reproducibility, stability, and enhancement.
Enabled applications in anthrax detection, chemical warfare agent stimulant detection, and glucose sensing.
Provided evidence for single-molecule SERS and explored its dynamic features, with theoretical support.

Conclusions:

Reproducible SERS substrates are crucial for analytical applications.
Understanding SERS mechanisms, including electromagnetic enhancement, is key to its advancement.
Single-molecule SERS is achievable and offers new insights into surface phenomena.