Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transcription factories.

David R F Carter1, Christopher Eskiw, Peter R Cook

  • 1Cranfield Health, Cranfield University, Cranfield, Bedfordshire, UK.

Biochemical Society Transactions
|July 18, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transcription clusters and developmental pathways - nature, nurture, noise.

Journal of cell science·2026
Same author

Epigenetic control of telomeric RNA maintains heterochromatin in telomerase-driven cancers.

Signal transduction and targeted therapy·2026
Same author

On the molecular basis of enduring memory in neurons, and cell fate in fibroblasts.

Nucleic acids research·2026
Same author

Generation of Clonal Cultures of Adherent or Suspension Cells Using Flat Sessile Drops for Assurance of Monoclonality.

Biotechnology and bioengineering·2025
Same author

DNA replication timing reveals genome-wide features of transcription and fragility.

Nature communications·2025
Same author

Bridging-mediated compaction of mitotic chromosomes.

Nucleus (Austin, Tex.)·2025
Same journal

TDP-43 proteinopathy as a biomarker and therapeutic target in amyotrophic lateral sclerosis.

Biochemical Society transactions·2026
Same journal

Advancing the monitoring of organelle contact sites in vitro and in vivo.

Biochemical Society transactions·2026
Same journal

Mechanisms influencing transient cytoplasmic protein targeting to intracellular lipid droplets.

Biochemical Society transactions·2026
Same journal

Replication associated nuclear DNA mismatch repair across kingdoms.

Biochemical Society transactions·2026
Same journal

Phosphatases of regenerating liver downregulate PTEN to promote tumorigenesis.

Biochemical Society transactions·2026
Same journal

Implications of Rho GTPase signaling in cancer immunotherapy.

Biochemical Society transactions·2026
See all related articles

Transcription factories are nuclear structures where genes are transcribed together. New techniques help characterize these factories, supporting models of gene transcription and chromosome organization.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Increasing evidence suggests that distinct transcription units are co-transcribed within specific nuclear domains.
  • These domains, termed transcription factories, are crucial for gene expression regulation.
  • Understanding their structure and function is key to comprehending genome organization.

Purpose of the Study:

  • To review recent advancements in detecting and characterizing transcription factories.
  • To discuss how these findings support existing models of transcription and chromosome organization.
  • To highlight the role of transcription factories in the spatial arrangement of the genome.

Main Methods:

  • Review of current literature on transcription factory research.

Related Experiment Videos

  • Analysis of novel techniques for visualizing and analyzing nuclear structures.
  • Integration of findings from various experimental approaches.

    • Main Results:

    • Various new techniques have been developed to identify and study transcription factories.
    • These methods provide insights into the composition and dynamics of these nuclear structures.
    • Evidence increasingly supports the role of transcription factories in coordinating gene activity.

    Conclusions:

    • Transcription factories represent a fundamental organizational principle in the nucleus.
    • They facilitate coordinated gene transcription and influence chromosome organization.
    • Further research using advanced techniques will refine our understanding of these structures and their impact on cellular function.