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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

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Related Experiment Video

Updated: Jul 3, 2026

Inguinal Subcutaneous White Adipose Tissue (ISWAT) Transplantation Model of Murine Islets
10:14

Inguinal Subcutaneous White Adipose Tissue (ISWAT) Transplantation Model of Murine Islets

Published on: February 16, 2020

Current challenges in islet transplantation.

Cristiane B Leitão1, Pablo Cure, Thipaporn Tharavanij

  • 1Diabetes Research Institute-University of Miami, 1450 NW 10th Avenue (R134), Miami, FL 33136, USA.

Current Diabetes Reports
|July 18, 2008
PubMed
Summary
This summary is machine-generated.

Allogeneic islet transplantation offers a promising treatment for unstable type 1 diabetes, stabilizing glucose and preventing hypoglycemia. Long-term insulin independence remains a challenge, driving current research to improve outcomes for type 1 diabetes patients.

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Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice

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Related Experiment Videos

Last Updated: Jul 3, 2026

Inguinal Subcutaneous White Adipose Tissue (ISWAT) Transplantation Model of Murine Islets
10:14

Inguinal Subcutaneous White Adipose Tissue (ISWAT) Transplantation Model of Murine Islets

Published on: February 16, 2020

A Method for Murine Islet Isolation and Subcapsular Kidney Transplantation
17:42

A Method for Murine Islet Isolation and Subcapsular Kidney Transplantation

Published on: April 13, 2011

Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice
11:57

Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice

Published on: July 23, 2017

Area of Science:

  • Immunology
  • Endocrinology
  • Transplantation Science

Background:

  • Allogeneic islet transplantation is an emerging therapy for type 1 diabetes mellitus (T1DM).
  • Current protocols achieve short-term insulin independence in a majority of recipients, but long-term success is limited.
  • Significant improvements in glucose control and quality of life are observed.

Purpose of the Study:

  • To evaluate the efficacy of allogeneic islet transplantation in unstable T1DM.
  • To identify current successes and limitations in islet transplantation programs.
  • To guide future research for sustained insulin independence.

Main Methods:

  • Utilized an
  • Edmonton-like
  • immunosuppressive protocol.
  • Administered one or two islet infusions per patient.
  • Monitored insulin independence, glucose stabilization, and hypoglycemia episodes.

Main Results:

  • Approximately 80% of patients achieved insulin independence post-transplantation.
  • Long-term insulin independence was sustained in only 10% of recipients.
  • Glucose normalization, HbA1c improvement, and prevention of severe hypoglycemia were consistently observed.

Conclusions:

  • Allogeneic islet transplantation effectively stabilizes glucose and improves quality of life in T1DM.
  • Sustaining long-term insulin independence is the primary challenge.
  • Ongoing efforts focus on overcoming limitations to enhance long-term transplant success.