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Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation
06:15

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation

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Fungal infections after lung transplantation

Amparo Solé1, Miguel Salavert

  • 1Pulmonary Transplant Unit, Hospital Universitario La Fe, 46009 Valencia, Spain. sole_amp@gva.es

Transplantation Reviews (Orlando, Fla.)
|July 18, 2008
PubMed

Insights

Lung transplantation (LT) patients face common fungal infections, with an incidence up to 30%. While invasive mycoses have declined, they remain a significant cause of mortality, necessitating effective antifungal strategies.

Area of Science:

  • Pulmonology
  • Infectious Diseases
  • Transplant Medicine

Background:

  • Lung transplantation (LT) is a vital treatment for end-stage pulmonary disease.
  • Infectious complications, particularly fungal infections, are prevalent post-LT due to immunosuppression.
  • Fungal infections occur in up to 30% of lung transplant recipients.

Purpose of the Study:

  • To review the evolving landscape of invasive fungal infections following lung transplantation.
  • To identify key risk factors, diagnostic approaches, and therapeutic strategies for fungal infections in LT recipients.
  • To highlight the changing spectrum of fungal pathogens, including emerging molds.

Main Methods:

  • Literature review focusing on invasive fungal infections in lung transplant recipients.
  • Analysis of incidence, causative agents, and mortality rates of fungal infections.
  • Examination of current practices in antifungal prophylaxis, diagnosis, and treatment.

Main Results:

  • The incidence of invasive fungal infections post-LT ranges up to 30%, though it has declined recently.
  • Candida and Aspergillus species are common, but unusual molds like Scedosporium are increasingly recognized.
  • Despite advances in antifungals, invasive mycoses are associated with high mortality rates.

Conclusions:

  • Fungal infections remain a critical challenge in lung transplant recipients.
  • Early diagnosis and appropriate antifungal treatment are crucial for improving outcomes.
  • Ongoing surveillance and research are needed to manage the changing spectrum of fungal pathogens.

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