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Longitudinal Research

Longitudinal Research

Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...

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Pharmacodynamics in Geriatric Patients: Effects of Age

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Related Experiment Video

Updated: Jul 3, 2026

Multi-Modal Home Sleep Monitoring in Older Adults

Multi-Modal Home Sleep Monitoring in Older Adults

Published on: January 26, 2019

The oldest old and the 90+ Study.

Claudia H Kawas¹

¹Department of Neurology, Department of Neurobiology and Behavior, University of California at Irvine, Irvine, CA, USA. michael.grundman@elan.com

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association

|July 22, 2008

Summary

This study investigates the oldest-old, focusing on Alzheimer's disease and dementing illnesses. The 90+ Study aims to continue vital scientific work through collaboration, building on Leon J. Thal's legacy.

Area of Science:

Neuroscience
Gerontology
Genetics

Background:

Alzheimer's disease and other dementing illnesses cause memory loss.
Leon J. Thal was a leader in dementia research.
The 90+ Study honors Thal's legacy by studying the oldest individuals.

Purpose of the Study:

To describe a clinical, genetic, and pathologic study of the oldest old.
To foster collaborations to continue research on dementing illnesses.

Main Methods:

Utilizing data from over 950 subjects.
Leveraging a brain repository and DNA collection.
Conducting clinical, genetic, and pathologic analyses.

Main Results:

Data from >950 subjects are available.

Related Experiment Videos

Last Updated: Jul 3, 2026

Multi-Modal Home Sleep Monitoring in Older Adults

Multi-Modal Home Sleep Monitoring in Older Adults

Published on: January 26, 2019

A brain repository and DNA collection are established.

The study focuses on the oldest population.

Conclusions:

The 90+ Study investigators are open to collaborations.
Collective efforts will advance scientific work in dementing illnesses.
Continuing Leon J. Thal's supported scientific endeavors.