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[Potential antiestrogens of the 1,2-diphenyl-1-pyridyl-but-1-ene type. 2. Biological testing]
W Schwarz1, R W Hartmann, H Schönenberger
1Sonderforschungsbereich 234, Institut für Pharmazie, Universität Regensburg.
Archiv Der Pharmazie
|April 1, 1991
Abstract:
Z-1-(4-hydroxyphenyl)-1-(4-resp. 3-pyridyl)-2-phenyl-but-1-enes Z-1 and Z-2 and their acetates Z-1a and Z-2a are weak estrogens (uterine weight test, immature mouse), which cause a marked tumor growth inhibition on the hormone-dependent MXT mammary carcinoma of the mouse. No or just slight estrogenic side effects determined by uterine weight are detectable in this tumor experiment.