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Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
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Related Experiment Video

Updated: Jul 3, 2026

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

Osteotropic cancers: from primary tumor to bone.

Jeroen T Buijs¹, Gabri van der Pluijm

¹Department of Urology, Leiden University Medical Center, Leiden, The Netherlands. J.T.Buijs@lumc.nl

|July 18, 2008

Summary

Cancer cells preferentially spread to distant organs, with bone metastases common in advanced breast and prostate cancer. This review explores the

Area of Science:

Oncology
Cancer Metastasis Research
Skeletal Biology

Background:

Bone metastases are a common complication in advanced breast and prostate cancer, significantly impacting patient morbidity.
The specific tropism of certain cancers for bone has been recognized for decades.
Understanding the mechanisms of bone metastasis is crucial for improving patient outcomes.

Purpose of the Study:

To review recent advancements in understanding the mechanisms of bone metastasis.
To discuss the role of the organ microenvironment in facilitating metastatic growth.
To utilize Stephen Paget's 'seed and soil' hypothesis as a framework for discussing bone metastasis.

Main Methods:

Literature review of recent studies on cancer cell-organ microenvironment interactions.

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Models of Bone Metastasis

Models of Bone Metastasis

Published on: September 4, 2012

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Last Updated: Jul 3, 2026

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model

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Models of Bone Metastasis

Models of Bone Metastasis

Published on: September 4, 2012

Analysis of research focusing on the 'seed and soil' hypothesis in the context of bone metastasis.

Synthesis of current knowledge on the molecular and cellular mechanisms underlying bone metastasis.

Main Results:

The interaction between cancer cells and the bone microenvironment is critical for successful metastasis.
Specific molecular and cellular cues within the bone 'soil' promote the growth of cancer 'seeds'.
Recent research has elucidated key pathways involved in this organ-specific colonization.

Conclusions:

The 'seed and soil' hypothesis remains a valuable model for understanding bone metastasis.
Targeting the interplay between cancer cells and the bone microenvironment holds therapeutic potential.
Continued research into the mechanisms of bone metastasis is essential for developing effective treatments.