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Published on: March 6, 2019
Cytokine single nucleotide polymorphisms in Iranian populations
Ali Akbar Amirzargar1, Mehrnaz Naroueynejad, Farideh Khosravi
1Immunogenetic Laboratory, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Iran. amirzargar_ali@yahoo.com
European Cytokine Network
|July 18, 2008
Summary
This study investigated cytokine gene polymorphisms in healthy Iranians. Results suggest the Iranian population
Area of Science:
- Immunogenetics
- Human Population Genetics
Background:
- Cytokines are key immunomodulatory molecules involved in host defense and immune disorders.
- Cytokine single nucleotide polymorphisms (SNPs) are studied for disease association and anthropological insights.
Purpose of the Study:
- To investigate the allele and genotype frequencies of various cytokine SNPs in different Iranian populations.
- To compare these frequencies with other ethnic groups, particularly Caucasians.
Main Methods:
- Collected samples from 455 healthy individuals across Tehran, Yazd, and Sistan and Balochistan regions in Iran.
- Utilized the Polymerase Chain Reaction - Sequence Specific Priming (PCR-SSP) method to analyze cytokine SNPs.
- Examined SNPs for IL-1alpha, IL-1beta, IL-1R, IL-1RA, IL-2, IL-4, IL-4RA, IL-6, IL-10, IL-12, TNF-alpha, TGF-beta, and IFN-gamma.
Main Results:
- Allele frequencies in Tehran and Yazd were largely similar, with exceptions for TGF-beta.
- Sistani & Baloch populations showed uniformity except for IL-1beta and IFN-gamma SNPs.
- Observed variations in IL-4, IL-6, IL-10, TGF-beta, and TNF-alpha frequencies when comparing Sistani & Baloch with Yazd populations.
Conclusions:
- Despite some regional variations, the overall cytokine gene polymorphism profile in the Iranian population appears similar to Caucasian populations, especially Italians.
- These findings contribute to understanding genetic diversity and potential disease associations within Iran.
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