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[Sickle cell anemia: cerebral angiography changes].

J O Alarcon-Adorno1, A Ferreira, M Muszkat

  • 1Hospital Infantil Menino Jesus (HIMJ), São Paulo, Brasil.

Arquivos De Neuro-Psiquiatria
|March 1, 1991
PubMed
Summary
This summary is machine-generated.

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Sickle cell disease can cause neurological issues, leading to a moyamoya-like pattern in brain blood vessels. This pattern indicates compensatory vascularization following artery blockages, highlighting the need for caution during diagnostic angiography.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Hematology

Background:

  • Sickle cell disease (SCD) is a genetic blood disorder associated with significant neurological complications.
  • Cerebrovascular disease is a known complication of SCD, often leading to ischemic or hemorrhagic events.

Observation:

  • Two cases of sickle cell disease presenting with neurological complications are detailed.
  • Cerebral angiograms revealed a distinctive moyamoya-like vascular pattern in both patients.

Findings:

  • The observed moyamoya-like pattern represents compensatory vascularization.
  • This pattern arises secondary to occlusion of the arteries at the base of the brain, a phenomenon seen in various underlying conditions.
  • The findings suggest a specific angiographic manifestation of cerebrovascular compromise in SCD.

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Implications:

  • The characteristic angiographic pattern may aid in the diagnosis and understanding of neurological complications in SCD.
  • Awareness of this pattern underscores the importance of considering SCD in patients with moyamoya-like findings.
  • The study emphasizes the inherent risks associated with cerebral angiography and the necessity for stringent safety protocols.