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Long-term functional evolution after an acute kidney injury: a 10-year study
Belén Ponte1, Carmen Felipe, Alfonso Muriel
1Nephrology Department, Ramón y Cajal University Hospital, Madrid, Spain.
Summary
Acute kidney injury (AKI) can lead to long-term renal function (RF) decline, even without prior kidney issues. Age, comorbidities, and initial recovery impact long-term outcomes.
Area of Science:
- Nephrology
- Internal Medicine
- Critical Care Medicine
Background:
- Long-term data on renal function (RF) after acute kidney injury (AKI) are limited.
- Factors influencing post-AKI renal recovery are not well-established.
Purpose of the Study:
- To investigate the long-term effects of AKI on RF.
- To identify predictors of functional outcome after AKI.
Main Methods:
- Retrospective review of RF in 187 AKI survivors over 10 years.
- Assessed RF using estimated glomerular filtration rate (eGFR) and KDOQI stages.
- Analyzed variables influencing RF using a regression model.
Main Results:
- At discharge, eGFR was significantly lower than baseline, with 38.4% recovering basal RF.
- Over an 8-year median follow-up, 46% definitively recovered RF; 61.6% presented some degree of renal dysfunction.
- Independent predictors of long-term RF included age, comorbidities, discharge eGFR, and follow-up duration.
Conclusions:
- AKI has long-term implications for RF, even in patients without pre-existing renal dysfunction.
- Age, comorbidities, and RF at discharge are key determinants of long-term renal outcomes post-AKI.
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