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Myricetin suppresses UVB-induced skin cancer by targeting Fyn

Sung Keun Jung1, Ki Won Lee, Sanguine Byun

  • 1Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea.

Cancer Research
|July 18, 2008
PubMed

Insights

Myricetin, a natural compound, effectively prevents skin cancer by inhibiting Fyn kinase activity. This phytochemical suppresses UVB-induced inflammation and tumor development, offering a promising chemopreventive strategy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Dermatology

Background:

  • Skin cancer is the most common human cancer in Americans.
  • Myricetin, a phytochemical found in foods like red wine, shows anticancer-promoting activity.
  • Understanding the molecular mechanisms of skin cancer chemoprevention is crucial.

Purpose of the Study:

  • To investigate the chemopreventive effects of myricetin against UVB-induced skin carcinogenesis.
  • To elucidate the molecular targets and pathways through which myricetin exerts its effects.
  • To evaluate myricetin's efficacy in preclinical models of skin cancer.

Main Methods:

  • Utilized mouse skin epidermal JB6 P+ cells and in vivo mouse skin models.
  • Assessed UVB-induced cyclooxygenase-2 (COX-2) expression, activator protein-1 (AP-1) and nuclear factor-kappaB (NF-κB) activation.
  • Performed Western blot, kinase assays, pull-down assays, and molecular docking to analyze Fyn kinase activity and myricetin's interaction.

Main Results:

  • Myricetin suppressed UVB-induced COX-2 expression and the activation of AP-1 and NF-κB in a dose-dependent manner.
  • Myricetin directly inhibited Fyn kinase activity, attenuating downstream signaling pathways.
  • In vivo studies confirmed myricetin's ability to inhibit Fyn kinase and reduce UVB-induced skin tumor incidence.

Conclusions:

  • Myricetin demonstrates significant chemopreventive activity against UVB-induced skin carcinogenesis.
  • The primary mechanism involves the direct targeting and inhibition of Fyn kinase by myricetin.
  • Myricetin represents a promising natural agent for the prevention of skin cancer.

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