Related Experiment Video
Updated: Jul 3, 2026

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
Published on: June 23, 2023
Psychosocial antecedents and adverse health consequences related to substance use
Judith S Brook1, Naomi S Saar, Chenshu Zhang
1Department of Psychiatry, New York University School of Medicine, 215 Lexington Ave, New York, NY 10016, USA. judith.brook@med.nyu.edu
Objectives:
We examined the relationship between psychosocial antecedents in earlier adolescence and problems related to substance use and related adverse health consequence (e.g., respiratory diseases, neurocognitive symptoms, and general malaise) in adulthood. We specifically focused on parent-child bonding in earlier adolescence and internalizing behaviors in later adolescence and their effects on problems related to substance use in the mid-20s and health problems in the mid-30s.
Methods:
Our team interviewed a community-based sample of 502 participants over a 30-year period (1975, 1983, 1985-1986, 1997, 2002, and 2005).
Results:
We found a strong relationship between internalizing behaviors in later adolescence and adverse health consequences in the mid-30s. Internalizing behaviors in later adolescence served as a mediator between low parent-child bonding in earlier adolescence and later adverse health consequences. Problems related to substance use in the late 20s and early 30s were related directly to later adverse health consequences and indirectly as mediators between earlier psychosocial difficulties (i.e., internalizing behaviors, externalizing behaviors, poor ego integration, and maladaptive coping) and later adverse health consequences.
Conclusions:
Policies and programs that address parent-child bonding and internalizing behaviors should be created to reduce problems related to substance use and, ultimately, later health problems.
Related Concept Videos
Stress and Mental Health
Individuals with depression often experience challenges in both their personal and professional...
Substance Use Disorders Affecting Sleep
Understanding the concepts of physical dependence,...
Stress Prevention and Stress Management Techniques IV
Drug Abuse and Addiction: Pharmacological Phenomena
Psychological and Sociocultural Causes of Schizophrenia
Drug Dependence
