Related Experiment Video
Updated: Jul 3, 2026
04:04
Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
[Intrapleural chemotherapy--current status and problems in Japan]
1Dept. of Medicine and Thoracic Oncology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|July 18, 2008
Summary
The study compared bleomycin, OK-432, and cisplatin+etoposide for malignant pleural effusion. OK-432 showed superior efficacy in pleural progression-free survival compared to other agents.
Area of Science:
- Oncology
- Thoracic Medicine
- Pharmacology
Context:
- Malignant pleural effusion management is challenging.
- Anti-neoplastic agents for pleurodesis efficacy and optimal protocols are debated.
- Intrapleural bleomycin and cisplatin are common in Japan, with institutional variations.
Purpose:
- To compare the efficacy of different intrapleural anti-neoplastic agents for malignant pleural effusion.
- To evaluate bleomycin (BLM), OK-432, and cisplatin+etoposide (PE) in a randomized trial.
- To establish evidence for optimal pleurodesis treatment protocols.
Summary:
- The JCOG 9515 trial randomized patients to BLM, OK-432, or PE arms.
- OK-432 demonstrated superior pleural progression-free survival compared to BLM and PE.
- Intrapleural combination therapy may offer advantages over single agents.
Impact:
- OK-432 is a potentially more effective agent for pleurodesis in malignant pleural effusion.
- Findings support the need for further randomized studies on intrapleural therapies.
- Results may influence future treatment guidelines for malignant pleural effusion.
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