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[Cancer chemoprevention-basic and clinical aspects]
Tetsuji Takayama1, Seisuke Okamura, Toshiya Okahisa
1Dept. of Gastroenterology and Oncology, Institutes of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|July 18, 2008
Summary
Cancer chemoprevention uses agents to inhibit or reverse cancer development, offering cost-benefits. Research now focuses on mechanism-based agents targeting molecular pathways and infections like hepatitis viruses.
Area of Science:
- Oncology
- Molecular Biology
- Preventive Medicine
Context:
- Cancer chemoprevention strategies are being developed to inhibit, delay, or reverse carcinogenesis.
- Advances in molecular biology have identified key signal transduction pathways involved in cancer development.
- Clinical trials for various cancers, including colorectal, prostate, and breast cancer, are evaluating chemopreventive agents.
Purpose:
- To explore the use of agents for cancer chemoprevention.
- To identify and develop mechanism-based chemopreventive agents.
- To investigate the role of chemoprevention in eradicating infectious agents linked to cancer.
Summary:
- Cancer chemoprevention involves using specific agents to halt or reverse the carcinogenic process.
- The field leverages recent molecular biology insights into carcinogenesis signaling pathways for targeted agent development.
- Clinical trials are actively assessing chemoprevention for major cancers, alongside its role in combating cancer-linked infections.
Impact:
- Potential for reduced cancer incidence and mortality through proactive intervention.
- Development of targeted therapies based on a deeper understanding of cancer molecular mechanisms.
- Broader application of chemoprevention strategies, including infectious disease eradication for cancer prevention.
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