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Multiple seizures after bupropion overdose in a small child

Henry A Spiller1, Scott E Schaeffer

  • 1Kentucky Regional Poison Center, Louisville, KY 40232-5070, USA. henry.spiller@nortonhealthcare.org

Pediatric Emergency Care
|July 18, 2008
PubMed

Insights

Bupropion overdose in children can cause severe toxicity, including seizures. This case highlights the need to recognize potential risks in pediatric bupropion ingestion.

Area of Science:

  • Pharmacology
  • Pediatric Toxicology
  • Emergency Medicine

Background:

  • Bupropion is a widely prescribed antidepressant.
  • Pediatric bupropion ingestion is typically associated with mild symptoms.
  • Severe toxicity from bupropion overdose in children is uncommon but possible.

Observation:

  • A pediatric patient ingested a significant amount of extended-release bupropion (1050 mg, 48 mg/kg).
  • The child presented with hallucinations, agitation, vomiting, tachycardia, and multiple seizures.

Findings:

  • This case demonstrates severe central nervous system toxicity, specifically seizures, following bupropion overdose in a child.
  • The extended-release formulation may influence the pharmacokinetic profile and toxicity in pediatric ingestions.

Implications:

  • Healthcare providers should be aware of the potential for severe bupropion toxicity in pediatric overdose cases.
  • Prompt recognition and management of bupropion overdose are crucial in pediatric patients.
  • Further research into the specific toxicity profile of extended-release bupropion in children is warranted.

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