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Multiple seizures after bupropion overdose in a small child
Henry A Spiller1, Scott E Schaeffer
1Kentucky Regional Poison Center, Louisville, KY 40232-5070, USA. henry.spiller@nortonhealthcare.org
Pediatric Emergency Care
|July 18, 2008
Summary
Bupropion overdose in children can cause severe toxicity, including seizures. This case highlights the need to recognize potential risks in pediatric bupropion ingestion.
Area of Science:
- Pharmacology
- Pediatric Toxicology
- Emergency Medicine
Background:
- Bupropion is a widely prescribed antidepressant.
- Pediatric bupropion ingestion is typically associated with mild symptoms.
- Severe toxicity from bupropion overdose in children is uncommon but possible.
Observation:
- A pediatric patient ingested a significant amount of extended-release bupropion (1050 mg, 48 mg/kg).
- The child presented with hallucinations, agitation, vomiting, tachycardia, and multiple seizures.
Findings:
- This case demonstrates severe central nervous system toxicity, specifically seizures, following bupropion overdose in a child.
- The extended-release formulation may influence the pharmacokinetic profile and toxicity in pediatric ingestions.
Implications:
- Healthcare providers should be aware of the potential for severe bupropion toxicity in pediatric overdose cases.
- Prompt recognition and management of bupropion overdose are crucial in pediatric patients.
- Further research into the specific toxicity profile of extended-release bupropion in children is warranted.
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