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Updated: Jul 3, 2026
Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
Published on: July 21, 2011
Synthesis and characterization of a smart contrast agent sensitive to calcium
Kirti Dhingra1, Martin E Maier, Michael Beyerlein
1Max Planck Institute for Biological Cybernetics, Department of Physiology of Cognitive Processes, Tübingen, Germany. Kirti.Dhingra@tuebingen.mpg.de
Abstract:
A novel first-generation Ca2+ sensitive contrast agent, Gd-DOPTRA has been synthesized and characterized. The agent shows approximately 100% relaxivity enhancement upon addition of Ca2+. The agent is selective and sensitive to Ca2+ also in the presence of Mg2+ and Zn2+. The relaxivity studies carried out in physiological fluids prove the prospects of the agent for in vivo measurements.
