Reagent switchable stereoselective beta(1,2) mannoside mannosylation: OH-2 of mannose is a privileged acceptor
Katie J Doores1, Benjamin G Davis
1Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Oxford, UK.
Organic & Biomolecular Chemistry
|July 18, 2008
Abstract:
The discovery of novel conditions for highly beta-stereoselective (>9 : 1) mannosylation of OH-2 of mannosides using a straightforward perbenzylthioglycoside donor has allowed ready assembly of beta-mannosyl oligosaccharides including the repeating trisaccharide motif of the O5 antigen of pathogen Klebsiella pneumoniae.
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