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Related Experiment Video

Updated: Jul 3, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Cognitive function in a systemic lupus erythematosus inception cohort.

Michelle Petri1, Mohammad Naqibuddin, Kathryn A Carson

  • 1Johns Hopkins University, Baltimore, MD, USA. mpetri@jhmi.edu

The Journal of Rheumatology
|July 18, 2008
PubMed
Summary

Cognitive impairment is common in systemic lupus erythematosus (SLE). Recently diagnosed SLE patients showed significant deficits in cognitive efficiency and sustained attention compared to healthy individuals.

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Area of Science:

  • Neuroscience
  • Rheumatology
  • Psychology

Background:

  • Systemic lupus erythematosus (SLE) frequently causes cognitive impairment, affecting 30-75% of patients.
  • Cognitive deficits in SLE can impact processing speed and efficiency.
  • Early detection of cognitive dysfunction is crucial for managing SLE.

Purpose of the Study:

  • To compare cognitive functioning between recently diagnosed SLE patients and healthy controls.
  • To identify specific cognitive domains affected in early-stage SLE.
  • To assess the utility of the Automated Neuropsychological Assessment Metrics (ANAM) in evaluating SLE-related cognitive changes.

Main Methods:

  • 111 recently diagnosed SLE patients and 79 healthy controls were evaluated.
  • The Automated Neuropsychological Assessment Metrics (ANAM), a computerized cognitive battery, was used.

Related Experiment Videos

Last Updated: Jul 3, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

  • Linear regression analysis compared ANAM throughput scores between groups, adjusting for demographic factors.

    • Main Results:

    • SLE patients scored significantly lower than controls on 4 of 9 ANAM subtests.
    • Impairments were noted in immediate recall, continuous performance, matching to sample, and the Sternberg subtest.
    • Deficits were particularly pronounced in cognitive efficiency, sustained attention, visuospatial working memory, and reaction time.

    Conclusions:

    • Recently diagnosed SLE patients exhibit significant cognitive deficits compared to controls.
    • These impairments in cognitive efficiency and sustained attention are present early in SLE, even without overt neuropsychiatric symptoms.
    • The findings highlight the need for early cognitive screening in SLE patients.