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[Estimation of selected parameters antioxidant barrier and lipid parameters in children with atherosclerosis risk

Anna Sierakowska-Fijałek1, Paweł Fijałkowski, Jan Błaszczyk

  • 1Uniwersytet Medyczny w Łodzi, II Zakład Medycyny Rodzinnej. annasierakowska@poczta.onet.pl

Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
|July 19, 2008
PubMed

Insights

Children with atherosclerosis risk factors show altered antioxidant activity. Glutathione peroxidase was higher, while catalase was lower, indicating potential early markers for this condition.

Area of Science:

  • Biochemistry
  • Pediatrics
  • Cardiovascular Research

Context:

  • Atherosclerosis is a leading cause of mortality globally.
  • Reactive oxygen species (ROS) play a significant role in atherosclerosis development.
  • Antioxidant defense mechanisms are crucial in mitigating ROS-induced damage.

Purpose:

  • To investigate the relationship between antioxidant barrier parameters and lipid profiles in children with atherosclerosis risk factors.
  • To identify potential biomarkers for early detection of atherosclerotic risk in pediatric populations.

Summary:

  • This study analyzed antioxidant enzyme activity (superoxide dismutase, glutathione peroxidase, catalase) and lipid levels (total cholesterol, triglycerides, HDL-C, LDL-C) in children with atherosclerosis risk factors.
  • Children with risk factors exhibited significantly higher total cholesterol, LDL-C, and triglycerides, and lower HDL-C.
  • Elevated glutathione peroxidase and reduced catalase activity were observed in children with risk factors, while superoxide dismutase and MDA levels showed no significant differences.

Impact:

  • Findings suggest that modified antioxidant activity in children with atherosclerosis risk factors may serve as an index of the antioxidant barrier.
  • These alterations could potentially act as early markers for atherosclerotic risk development in children.
  • This research highlights the importance of monitoring antioxidant status in pediatric populations at risk for cardiovascular disease.
Abstract

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