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Updated: Jul 3, 2026
09:54
Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
Published on: December 3, 2019
[Lipodystrophy in HIV infected children]
1Medical University of Warsaw, Infectious Diseases Hospital in Warsaw, Department of Childrens' Infectious Diseases, Poland. jolantapopielska@wp.pl
Summary
Lipodystrophy affects nearly half of HIV-infected children on antiretroviral treatment (ART), particularly those on specific drug combinations. This highlights the need for new therapeutic options to mitigate these metabolic side effects.
Area of Science:
- Pediatric Infectious Diseases
- Metabolic Disorders
- HIV/AIDS Research
Context:
- Antiretroviral treatment (ART) for HIV can lead to metabolic disturbances, including lipodystrophy.
- Lipodystrophy poses risks for early atherosclerosis and ischemic heart disease.
Purpose:
- To estimate the prevalence of lipodystrophy in HIV-infected children receiving highly active antiretroviral therapy (HAART).
- To identify risk factors associated with lipodystrophy in this pediatric population.
- To evaluate diagnostic methods for lipodystrophy.
Summary:
- A study of 52 children (aged 3-18) found lipodystrophy in 46%, with a mixed form being most common.
- Risk factors included treatment with d4T, ddi, and rtv, and were associated with higher triglyceride levels.
- Skin fold measurements were useful, but Bioelectrical Impedance Analysis (BIA) was not.
Impact:
- Findings indicate a high prevalence of lipodystrophy, challenging the perception of therapeutic success in effectively treated children.
- Highlights the need for alternative therapeutic strategies to manage ART-related metabolic complications.
- Suggests that skin fold measurements are a practical diagnostic tool for lipodystrophy in children.
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