[Langerhans' cell histiocytosis--diagnostic and treatment difficulties]

Langerhans' cell histiocytosis [(LCH), histiocytosis X] is a very rare disease, which can involve any side and organ of the body. LCH may appear as an isolated leasion or as a widespread systemic disease. Focus in the bone as eosinophilic granuloma can be separate or be involved only as a part of generalized disease. The aim of this study was describe diagnostic and treatment difficulties in two patients suffering from LCH. The first patient was 28-years-old man who had been treated by reason of tumor on the left angle of mandible in 2005 year. The second patient was a 2-years-old-child who had directed because of gomphiasis deciduous molar teeth in lower and upper jaws in 2005 year. After diagnosis child was treatment by chemotherapy and stay in remission.

1. In differential diagnosis of infiltrations and osteolytic losses of maxilla and mandible one should take into account LCH. 2. Differential localization and non characteristic symptoms can cause the late diagnosis and aggravate the prognosis of this severe disease. 3. Dentist in his practice should keep oncological vigilance because of the fact that he may be the first doctor for patients with LCH.