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Related Concept Videos

Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Nervous Tissue: Myelin01:25

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The myelin sheath is a multilayered lipid and protein covering that insulates the axon of a neuron, enhancing the speed of nerve impulse conduction. Axons without this sheath are referred to as unmyelinated. Two types of neuroglia, Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) are responsible for producing myelin sheaths.
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...
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Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
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Laminins are the Adhesive Proteins of Basal Lamina00:55

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Laminins are heterotrimeric proteins with high molecular mass found in the extracellular matrix. Each laminin molecule is composed of three chains, viz. alpha, beta, and gamma, coded by five, four, and three paralogous genes, respectively. Laminins are categories based on the compositions of the three chains.
In humans, the five forms of alpha chains are LAMA 1, LAMA 2, LAMA 3, LAMA 4, and LAMA 5. The four forms of beta chains are LAMB 1, LAMB 2, LAMB 3, and LAMB 4. The three forms of gamma...
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Adherens Junctions are Dynamic
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Anchoring Junctions

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Related Experiment Video

Updated: Jul 3, 2026

Preparation and Immunostaining of Myelinating Organotypic Cerebellar Slice Cultures
09:41

Preparation and Immunostaining of Myelinating Organotypic Cerebellar Slice Cultures

Published on: March 20, 2019

Axonal cell-adhesion molecule L1 in CNS myelination.

G Barbin1, M S Aigrot, P Charles

  • 1Biologie des Interactions Neurones/Glie, UPMC, INSERM U-495, Hôpital de la Salpêtrière, Paris Cedex 13.

Neuron Glia Biology
|July 19, 2008
PubMed
Summary
This summary is machine-generated.

Axonally expressed L1 cell adhesion molecule is crucial for initiating central nervous system (CNS) myelination. Blocking L1 function inhibits myelination, suggesting its role in early oligodendrocyte development.

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Last Updated: Jul 3, 2026

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Published on: March 20, 2019

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09:14

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Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study
11:10

Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study

Published on: June 29, 2016

Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Biology

Background:

  • Adhesion molecules on axons are potential mediators of myelinating cell-axon interactions.
  • L1 cell-adhesion molecule (a neural cell adhesion molecule) is vital for neuronal development and peripheral nervous system (PNS) myelination.

Purpose of the Study:

  • To investigate the role of axonally expressed L1 in central nervous system (CNS) myelination.
  • To elucidate the molecular mechanisms by which L1 influences CNS myelination.

Main Methods:

  • Co-culture of murine oligodendrocytes and neurons.
  • Immunohistochemistry to detect L1 expression patterns.
  • Inhibition of L1 function using anti-L1 antibodies and L1-Fc fusion proteins.
  • Analysis of mitogen-activated protein (MAP) kinase pathway activation in oligodendrocytes.

Main Results:

  • L1 is expressed on neurites before myelination and downregulated during myelination.
  • Inhibition of L1 prevents myelination in vitro.
  • L1-Fc fusion protein inhibits lysophosphatidic acid-induced MAP-kinase pathway activation in oligodendrocytes.

Conclusions:

  • Axonally expressed L1 is essential for the initiation of CNS myelination.
  • L1 may mediate CNS myelination through modulation of oligodendroglial phosphoprotein dephosphorylation, potentially involving the MAP-kinase pathway.