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Related Concept Videos

The Proteasome01:13

The Proteasome

Eukaryotic cells can degrade proteins through several pathways. One of the most important among these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. This involves participation of a series of enzymes including— E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3 (ubiquitin...
The Proteasome02:18

The Proteasome

Eukaryotic cells can degrade proteins through several pathways. One of the most important amongst these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. A series of enzymes carry out the ubiquitination of the target proteins - E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
The Proteasome02:18

The Proteasome

Eukaryotic cells can degrade proteins through several pathways. One of the most important amongst these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. A series of enzymes carry out the ubiquitination of the target proteins - E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Regulated Protein Degradation02:58

Regulated Protein Degradation

It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...

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Related Experiment Video

Updated: Jul 3, 2026

Monitoring of Ubiquitin-proteasome Activity in Living Cells Using a Degron (dgn)-destabilized Green Fluorescent Protein (GFP)-based Reporter Protein
10:25

Monitoring of Ubiquitin-proteasome Activity in Living Cells Using a Degron (dgn)-destabilized Green Fluorescent Protein (GFP)-based Reporter Protein

Published on: November 10, 2012

The ubiquitin-proteasome system in cardiac dysfunction.

Giulia Mearini1, Saskia Schlossarek, Monte S Willis

  • 1Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Biochimica Et Biophysica Acta
|July 19, 2008
PubMed
Summary

Cellular protein balance is vital for health. This review explores the ubiquitin-proteasome system (UPS) and autophagy in heart disease, revealing their parallel activation.

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Last Updated: Jul 3, 2026

Monitoring of Ubiquitin-proteasome Activity in Living Cells Using a Degron (dgn)-destabilized Green Fluorescent Protein (GFP)-based Reporter Protein
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Area of Science:

  • Cellular Biology
  • Biochemistry

Background:

  • Protein homeostasis, regulated by synthesis and degradation, is crucial for cellular function.
  • Molecular chaperones, the ubiquitin-proteasome system (UPS), and lysosomes maintain protein quality control.
  • The UPS and lysosomes were thought to function independently, degrading different protein types.

Purpose of the Study:

  • To review the role of the ubiquitin-proteasome system (UPS) in cardiac health and disease.
  • To summarize recent findings on the interplay between UPS and autophagy in cardiac conditions.

Main Methods:

  • Literature review focusing on the ubiquitin-proteasome system (UPS).
  • Analysis of studies investigating protein degradation pathways in cardiac physiology and pathology.
  • Synthesis of recent evidence on parallel UPS and autophagy activation in heart disease.

Main Results:

  • The UPS is increasingly recognized for its role in cell proliferation, stress adaptation, and cell death.
  • UPS dysfunction is implicated in cardiac disease.
  • Autophagy is essential for maintaining cardiac structure and function.

Conclusions:

  • The ubiquitin-proteasome system (UPS) is a significant regulator in cellular processes, including cardiac function.
  • Emerging evidence suggests coordinated activation of the UPS and autophagy in cardiac disease.
  • Understanding these pathways offers potential therapeutic targets for heart conditions.