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Related Concept Videos

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Related Experiment Video

Updated: Jul 3, 2026

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

Diffusion-based tractography in neurological disorders: concepts, applications, and future developments.

Olga Ciccarelli1, Marco Catani, Heidi Johansen-Berg

  • 1Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, London, UK. o.ciccarelli@ion.ucl.ac.uk

The Lancet. Neurology
|July 19, 2008
PubMed
Summary
This summary is machine-generated.

Diffusion tractography reconstructs brain and spinal cord white matter pathways. This review covers its clinical uses for neurological diseases like stroke and multiple sclerosis, and future potential.

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Last Updated: Jul 3, 2026

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Published on: November 8, 2012

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Area of Science:

  • Neuroimaging
  • Neuroscience
  • Medical Physics

Background:

  • Diffusion-based tractography is a neuroimaging technique for reconstructing white matter pathways.
  • It offers potential clinical applications in studying neurological disorders.

Purpose of the Study:

  • To review the limitations of diffusion tractography.
  • To describe its current clinical applications in common neurological diseases.
  • To highlight future opportunities for this technique.

Main Methods:

  • Review of existing literature on diffusion-based tractography.
  • Analysis of clinical applications in stroke, multiple sclerosis, epilepsy, neurodegenerative diseases, and spinal cord disorders.

Main Results:

  • Tractography has significant limitations that need to be addressed.
  • Current applications demonstrate its value in diagnosing and understanding neurological conditions.
  • Future opportunities lie in refining techniques and expanding clinical utility.

Conclusions:

  • Diffusion tractography is a valuable tool in clinical neurology.
  • Further research and technological advancements will enhance its diagnostic and research capabilities.
  • It holds promise for advancing our understanding and treatment of neurological diseases.