Related Experiment Videos
[Necrotizing folliculitis in Behçet's disease].
1Service de médecine interne, CHU de la Pitié-Salpêtrière, Université Pierre-et-Marie-Curie Paris-VI, 75651 Paris cedex 13, France. salim.trad@psl.aphp.fr
Summary
A Behcet's disease patient developed a severe skin infection from Staphylococcus aureus. Mandatory bacteriological analysis is crucial for accurate diagnosis when specific criteria are absent.
Area of Science:
- Dermatology
- Infectious Diseases
- Rheumatology
Background:
- Behcet's disease is a chronic inflammatory disorder.
- Patients may present with mucocutaneous lesions and systemic involvement.
- Disease flares can mimic or be complicated by infections.
Observation:
- A 24-year-old male with known Behcet's disease presented with scrotal ulceration and inguinal folliculitis.
- The folliculitis exhibited a necrotizing course.
- The patient had been lost to follow-up for one year.
Findings:
- Skin infection was diagnosed, caused by community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA).
- The identified Staphylococcus aureus strain carried Panton-Valentine leukocidin (PVL) genes.
- The clinical presentation initially suggested a Behcet's disease flare-up.
Implications:
- This case highlights the importance of considering infectious etiologies in Behcet's disease patients.
- Bacteriological analysis is essential for accurate diagnosis, especially when diagnostic criteria for Behcet's disease are not definitively met.
- Prompt identification of CA-MRSA is critical for appropriate treatment and preventing complications.
Related Concept Videos
Endocarditis II: Clinical Features of Infective Endocarditis
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Inflammatory Bowel Disease II: Crohn's Disease
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Staphylococcal Skin Infections
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Acne Infection
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Inflammatory Bowel Disease III: Crohn's Disease
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...