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Isolation of Viable Multicellular Glands from Tissue of the Carnivorous Plant, Nepenthes

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Published on: December 22, 2013

Two novel bibenzyls from Dendrobium trigonopus.

Jiang-Miao Hu¹, Ji-Jun Chen, Hong Yu

¹State Key Laboratory of Phytochemistry and Plant Resource in West China, Kunming Institute of Botany, the Chinese Academy of Science, Kunming, China.

Journal of Asian Natural Products Research

|July 19, 2008

Summary

Two new bibenzyl compounds, trigonopols A and B, were isolated from Dendrobium trigonopus stems. Trigonopol A demonstrated significant in vitro antiplatelet aggregation activity.

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Area of Science:

Natural Product Chemistry
Pharmacology

Background:

Dendrobium species are a rich source of bioactive natural products.
Bibenzyls are a class of compounds with diverse pharmacological properties.

Purpose of the Study:

To isolate and characterize novel compounds from Dendrobium trigonopus stems.
To evaluate the antiplatelet aggregation activity of isolated compounds.

Main Methods:

Phytochemical investigation of Dendrobium trigonopus stems.
Structure elucidation using spectroscopic methods (NMR, MS).
In vitro antiplatelet aggregation assay.

Main Results:

Two new bibenzyl compounds, trigonopols A (1) and B (2), were identified.
Seven known compounds were also isolated, with compounds 6, 8, and 9 being new to this species.
Trigonopol A exhibited 67.55% inhibition of platelet aggregation at 1.4337 x 10(-3) M.

Conclusions:

The study successfully identified novel bibenzyls from Dendrobium trigonopus.
Trigonopol A shows potential as an antiplatelet agent.