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The proteasome and its role in the degradation of oxidized proteins

Tobias Jung1, Tilman Grune

  • 1Institute for Biological Chemistry and Nutrition, Biofunctionality and Food Safety (140f), University of Hohenheim, Stuttgart, Germany.

IUBMB Life
|July 19, 2008
PubMed

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Eukaryotic cells can degrade proteins through several pathways. One of the most important amongst these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
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The Proteasome

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The proteasome is an...
Regulated Protein Degradation02:58

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Regulated Protein Degradation02:58

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It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
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