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Updated: Jul 3, 2026

An Improved Method to Isolate Mitochondrial Contact Sites
Published on: June 16, 2023
No evidence of association between frontotemporal dementia and major European mtDNA haplogroups
1Department of Cell Biology, University of Calabria, Rende, Italy. pinarose@unical.it
Background And Purpose:
Mitochondrial DNA (mtDNA) inherited variability (haplogroup/sub-haplogroup) is currently emerging as not being neutral with respect to several complex traits like neurodegenerative diseases. Here we investigated the association of European mtDNA haplogroups/sub-haplogroups with frontotemporal dementia (FTD).
Method And Results:
A case-control study was carried out on 114 patients with FTD (68 sporadic and 46 familial) and 180 controls, matched for age, gender and ethnicity. No association was found.
Conclusions:
European mtDNA haplogroups/sub-haplogroups are unlikely to play a major role in the risk of developing the disease.
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