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Updated: Jul 3, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
Sulfamethoxazole/Trimethoprim induced liver failure: a case report
Salaheldin Abusin1, Swapna Johnson
1Department of Medicine, Stroger Hospital of Cook County, 1901 W Harrison St, Chicago, IL, 60612, USA. sayabusin@hotmail.com.
Abstract:
Sulfamethoxazole/Trimethoprim (SMX/TMP) is a commonly used antibiotic, its' known adverse reaction of hepatotoxicity leading to acute liver failure is considered rare. We present a case of a 22 year old female who developed jaundice and acute liver failure one week after taking SMX/TMP for a UTI. After an extensive work up, a clinical diagnosis of SMX/TMP induced liver failure was reached. Over the course of several weeks she made a good clinical and biochemical recovery with supportive care. In this case report we describe her clinical presentation and course, and present a brief review of the literature.
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