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Updated: Jul 3, 2026

Observing and Quantifying Fibroblast-mediated Fibrin Gel Compaction
Published on: January 16, 2014
A review of fibroblast-populated collagen lattices
John C Dallon1, H Paul Ehrlich
1Department of Surgery, Division of Plastic Surgery, Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.
Abstract:
Bell's introduction of the fibroblast-populated collagen lattice (FPCL) has facilitated the study of collagen-cell interactions. As a result of the numerous modifications of the casting of FPCLs, the in vivo applications of these in vitro findings have been confusing. Here experimental FPCL contraction findings are viewed in regard to three proposed mechanisms responsible for lattice contraction. The cellular mechanisms responsible for generating FPCL contraction are cell contraction, cell tractional forces related to cell locomotion, and initial cell elongation and spreading.
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