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Related Concept Videos

iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Related Experiment Video

Updated: Jul 3, 2026

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
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Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Published on: February 17, 2022

Cellular therapy of systemic sclerosis.

Jacob M van Laar1, Alan Tyndall

  • 1Department of Rheumatology, Felix-Platter Spital, University of Basel, Burgfelderstrasse 101, Basel 4012 Switzerland.

Current Rheumatology Reports
|July 22, 2008
PubMed
Summary
This summary is machine-generated.

Cell-based therapies show promise for autoimmune diseases. Hematopoietic stem cell transplantation offers long-term benefits but carries risks, while mesenchymal stromal cells are being explored for their safety and regenerative potential.

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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Area of Science:

  • Immunology and Rheumatology
  • Cell-based regenerative medicine

Background:

  • Rheumatic autoimmune diseases involve aggressive immune reactions.
  • Cell-based therapies aim to dampen these reactions and induce tolerance.
  • Current treatments have limitations, necessitating novel therapeutic approaches.

Purpose of the Study:

  • To review the role of cell-based therapies in severe rheumatic autoimmune diseases.
  • To evaluate the efficacy and safety of hematopoietic stem cell transplantation (HSCT).
  • To explore the potential of mesenchymal stromal cells (MSCs) in managing autoimmune conditions.

Main Methods:

  • Review of existing literature on cell-based therapies for autoimmune diseases.
  • Analysis of outcomes from over 1000 patients treated with immunoablative therapy and autologous HSCT.
  • Examination of ongoing clinical trials comparing HSCT with conventional treatments.
  • Assessment of pilot studies on mesenchymal stromal cells for their anti-inflammatory and regenerative properties.

Main Results:

  • Autologous HSCT has demonstrated long-term improvements in disease activity for severe autoimmune diseases.
  • HSCT is associated with significant treatment-related toxicity and mortality.
  • Prospective randomized controlled trials are underway to compare HSCT efficacy and safety against standard treatments.
  • Mesenchymal stromal cells show potential due to their anti-inflammatory and tissue regenerative capabilities.

Conclusions:

  • Hematopoietic stem cell transplantation is a viable, albeit high-risk, option for severe autoimmune diseases.
  • Mesenchymal stromal cell therapies represent a promising alternative with a potentially better risk/benefit profile.
  • Further research and clinical trials are essential to optimize cell-based therapeutic strategies for autoimmune conditions.