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Related Experiment Video

Updated: Jul 3, 2026

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
12:27

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

Published on: June 8, 2022

S1P and eNOS regulation.

Junsuke Igarashi1, Thomas Michel

  • 1Department of Cardiovascular Physiology, Kagawa University Faculty of Medicine, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793 Japan. igarashi@med.kagawa-u.ac.jp

Biochimica Et Biophysica Acta
|July 22, 2008
PubMed
Summary

Sphingosine 1-phosphate (S1P) activates endothelial nitric oxide synthase (eNOS), regulating vascular homeostasis. This review explores S1P

Area of Science:

  • Cardiovascular Biology
  • Molecular Signaling

Background:

  • Nitric oxide (NO) is crucial for vascular homeostasis.
  • Endothelial nitric oxide synthase (eNOS) produces NO in response to various stimuli.
  • Sphingosine 1-phosphate (S1P) is a newly identified activator of eNOS.

Purpose of the Study:

  • To review the role of S1P and its receptors in eNOS activation.
  • To analyze S1P-mediated regulatory mechanisms of eNOS.
  • To discuss the implications of S1P-eNOS signaling in cardiovascular (patho)physiology.

Main Methods:

  • Literature review of studies on S1P, S1P receptors, and eNOS.
  • Analysis of signaling pathways involved in S1P-induced eNOS activation.
  • Synthesis of current knowledge on the physiological and pathophysiological relevance.

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Fluorescence-Based Measurements of Phosphatidylserine/Phosphatidylinositol 4-Phosphate Exchange Between Membranes

Published on: March 14, 2021

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Last Updated: Jul 3, 2026

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
12:27

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

Published on: June 8, 2022

Fluorescence-Based Measurements of Phosphatidylserine/Phosphatidylinositol 4-Phosphate Exchange Between Membranes
08:49

Fluorescence-Based Measurements of Phosphatidylserine/Phosphatidylinositol 4-Phosphate Exchange Between Membranes

Published on: March 14, 2021

Main Results:

  • S1P activates eNOS through specific S1P receptors.
  • S1P signaling influences key vascular functions regulated by NO.
  • The interaction between S1P and eNOS has significant implications for cardiovascular health and disease.

Conclusions:

  • S1P is a significant modulator of eNOS activity.
  • Understanding S1P-eNOS pathways offers therapeutic potential for cardiovascular diseases.
  • Further research is warranted to fully elucidate the complex interplay.