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Updated: Jul 3, 2026
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Published on: March 10, 2026
Recurrent lymphomatoid granulomatosis and isolated CNS involvement
L H Sekhon1, M K Morgan, E L Salisbury
1Department of Surgery, The University of Sydney, Australia.
Summary
Lymphomatoid granulomatosis rarely affects the central nervous system (CNS). This case highlights isolated CNS involvement with unique lesion behavior, showing spontaneous regression and recrudescence.
Area of Science:
- Neurology
- Pathology
- Oncology
Background:
- Lymphomatoid granulomatosis typically affects the lungs.
- Central nervous system (CNS) involvement is uncommon.
- Isolated CNS involvement is exceptionally rare.
Purpose of the Study:
- To report a rare case of lymphomatoid granulomatosis with isolated CNS involvement.
- To describe the unusual temporal dynamics of CNS lesions in this patient.
Main Methods:
- Case report of a 65-year-old male patient.
- Clinical and radiological assessment of CNS lesions.
- Analysis of lesion behavior over time.
Main Results:
- The patient presented with isolated CNS involvement of lymphomatoid granulomatosis.
- Observed were unique patterns of lesion regression and recrudescence.
- These changes occurred independently of therapeutic interventions.
Conclusions:
- Lymphomatoid granulomatosis can present with isolated CNS disease.
- The spontaneous temporal fluctuation of lesions is a noteworthy characteristic.
- This case expands the understanding of lymphomatoid granulomatosis presentations.
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